Kuvan® (sapropterin dihydrochloride) Patient
Baton Rouge, Louisiana
Lauren is a bright, energetic young adult with a hectic schedule, big life plans, and a very bright future. She graduated high school as valedictorian and is working toward a bachelor of science degree in chemistry. Since initiating treatment with KUVAN, her Phe levels have decreased significantly.
Because high Phe levels are toxic to the brain, some patients never reach their full intellectual potential and suffer from other related social and neurocognitive problems. Lauren keeps her Phe levels down by taking Kuvan and maintaining her low Phe diet.
“She’s an extremely bright young woman and we want to give her every opportunity to reach her intellectual potential,” says her physician, Dr. Andersson. “Kuvan has been a great opportunity for Lauren to get her Phe levels down significantly lower than they were before.”
Lauren says that now she knows it is possible to have PKU and still live a normal life. “I am living proof,” she says.
“I would like to thank everyone at BioMarin for continuing to work tirelessly to enhance the lives of PKU patients everywhere. I’ve always known that I can do anything while living with PKU, but your hard work has certainly helped me to succeed.”
Full Indication and Important Safety Information
Kuvan® (sapropterin dihydrochloride) Tablets for Oral Use and Powder for Oral Solution is approved to reduce blood Phe levels in patients with hyperphenylalaninemia (HPA) due to tetrahydrobiopterin- (BH4-) responsive Phenylketonuria (PKU). Kuvan is to be used with a Phe-restricted diet.
Important Safety Information
High blood Phe levels are toxic to the brain and can lead to lower intelligence and decrease in the ability to focus, remember and organize information. Any change you make to your diet may impact your blood Phe level. Follow your doctor’s instructions carefully. Your doctor and dietitian will continue to monitor your diet and blood Phe levels throughout your treatment with Kuvan.
If you have a fever, or if you are sick, your Phe level may go up. Tell your doctor and dietitian as soon as possible so they can see if they have to adjust your treatment to help keep your blood Phe levels in the desired range.
Kuvan is a prescription medicine and should not be taken by people who are allergic to any of its ingredients. Tell your doctor if you have ever had liver or kidney problems, are nursing or pregnant or may become pregnant, have poor nutrition or are anorexic. Your doctor will decide if Kuvan is right for you. Tell your doctor about all the medicines you take.
The most common side effects reported when using Kuvan are headache, diarrhea, abdominal pain, upper respiratory tract infection (like a cold), throat pain, vomiting, and nausea.
To report SUSPECTED ADVERSE REACTIONS, contact BioMarin Pharmaceutical Inc. at 1-866-906-6100, or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch
Kuvan is available by prescription only. To learn more, please visit www.kuvan.com for full prescribing information. If you have any questions about this information, please talk with your doctor.